Roy L. Kisliuk: search on Z-Library

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1

Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin-4(3h)-one as inhibitors of folate metabolizing enzymes

Aleem Gangjee, Ying Wang, Sherry F. Queener, Roy L. Kisliuk

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 562 KB

english, 2006

2

ChemInform Abstract: Synthesis of Novel, Nonclassical 2-Amino-4-oxo-6-(arylthio)ethylpyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Thymidylate Synthase.

Aleem Gangjee, Nauzer P. Dubash, Roy L. Kisliuk

Journal:

Year:

2001

File:

PDF, 30 KB

2001

3

Synthesis of 2-amino-4-oxo-5-substitutedbenzylthiopyrrolo[2,3-d]-pyrimidines as potential inhibitors of thymidylate synthase

Aleem Gangjee, Hiteshkumar D. Jain, Jaclyn Phan, Roy L. Kisliuk

Journal:

Journal of Heterocyclic Chemistry

Year:

2005

Language:

english

File:

PDF, 59 KB

english, 2005

4

19F NMR studies of the binding of 5-fluoro-2′-deoxyuridylate to thymidylate synthase

Michael J. Beckage, Michael Blumenstein, Roy L. Kisliuk

Journal:

Molecular and Cellular Biochemistry

Year:

1980

Language:

english

File:

PDF, 303 KB

english, 1980

5

Tetrahydrohomofolate polyglutamates as inhibitors of thymidylate synthase and glycinamide ribonucleotide formyltransferase in Lactobacillus casei

Janet Thorndike, Roy L. Kisliuk, Yvette Gaumont, James R. Piper, Madhavan G. Nair

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 825 KB

english, 1990

6

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Gangjee, Aleem, Li, Wei, Kisliuk, Roy L., Cody, Vivian, Pace, Jim, Piraino, Jennifer, Makin, Jennifer

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 4.05 MB

english, 2009

7

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Xin Zhang, Xilin Zhou, Roy L. Kisliuk, Jennifer Piraino, Vivian Cody, Aleem Gangjee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.03 MB

english, 2011

8

Synergistic interactions among antifolates

Journal:

Pharmacology & Therapeutics

Year:

2000

Language:

english

File:

PDF, 177 KB

english, 2000

9

A calorimetric study of the binding of 2′-deoxyuridine-5′-phosphate and its analogs to thymidylate synthetase

Norman V. Beaudette, Neal Langerman, Roy L. Kisliuk

Journal:

Archives of Biochemistry and Biophysics

Year:

1980

Language:

english

File:

PDF, 683 KB

english, 1980

10

5-Arylthio Substituted 2-Amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents

Gangjee, Aleem, Devraj, Rajesh, McGuire, John J., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

11

Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs

Chaykovsky, Michael, Rosowsky, Andre, Papathanasopoulos, Nickolas, Chen, Katherine K. N., Modest, Edward J., Kisliuk, Roy L., Gaumont, Yvette

Journal:

Journal of Medicinal Chemistry

Year:

1974

Language:

english

File:

PDF, 677 KB

english, 1974

12

Synthesis of Classical and Nonclassical 2-Amino-4-oxo-6-benzylthieno[2,3-d]pyrimidines as Potential Thymidylate Synthase Inhibitors.

Aleem Gangjee, Yibin Qiu, Roy L. Kisliuk

Journal:

Year:

2005

File:

PDF, 24 KB

2005

13

[Part 1: Biological Sciences] || Association of RNA with Thymidylate Synthase from Methotrexate-Resistant Streptococcus faecium

K. Narasimha Rao and Roy L. Kisliuk

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 994 KB

english, 1983

14

Polyglutamyl derivatives of tetrahydrofolate as substrates for Lactobacillus casei thymidylate synthase

Kisliuk, Roy L., Gaumont, Yvette, Lafer, Eileen, Baugh, Charles M., Montgomery, John A.

Journal:

Year:

1981

Language:

english

File:

PDF, 729 KB

english, 1981

15

Methotrexate analogs. 12. Synthesis and biological properties of some aza homologs

Martinelli, Jack E., Chaykovsky, Michael, Kisliuk, Roy L., Gaumont, Yvette, Gittelman, Marc C.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 803 KB

english, 1979

16

Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation †

Reynolds, Robert C., Campbell, Shiela R., Fairchild, Ralph G., Kisliuk, Roy L., Micca, Peggy L., Queener, Sherry F., Riordan, James M., Sedwick, W. David, Waud, William R., Leung,, Dixon, Richard W.,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 4.89 MB

english, 2007

17

N α -Ipteroyltetra (γ-Glutamyl)]-Lysine as a Ligand for the Purification of Thymidylate Synthetase by Affinity Chromatography

Plante, Laurence T., Gaumont, Yvette, Kisliuk, Roy L.

Journal:

Preparative Biochemistry

Year:

1978

Language:

english

File:

PDF, 270 KB

english, 1978

18

Synthesis of classical and nonclassical 2-amino-4-oxo-6-benzylthieno-[2,3-d]pyrimidines as potential thymidylate synthase inhibitors

Aleem Gangjee, Yibin Qiu, Roy L. Kisliuk

Journal:

Journal of Heterocyclic Chemistry

Year:

2004

Language:

english

File:

PDF, 97 KB

english, 2004

19

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates

Aleem Gangjee, Jie Yang, John J. McGuire, Roy L. Kisliuk

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 201 KB

english, 2006

20

Study of thymidylate synthetase-function by laser Raman spectroscopy

Rajendra K. Sharma, Roy L. Kisliuk, Surendra P. Verma, Donald F.H. Wallach

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1975

Language:

english

File:

PDF, 466 KB

english, 1975

21

Folate analogs altered in the C9-N10 bridge region: N10-tosylisohomofolic acid and N10-tosylisohomoaminopterin

Nair, M. G., O'Neal, P. Colleen, Baugh, C. M., Kisliuk, Roy L., Gaumont, Y., Rodman, Michael

Journal:

Journal of Medicinal Chemistry

Year:

1978

Language:

english

File:

PDF, 707 KB

english, 1978

22

Studies on the antitumor effects of analogues of 5,8-dideazaisofolic acid and 5,8-dideazaisoaminopterin

Robert L. Hagan, John B. Hynes, Meade Pimsler, Roy L. Kisliuk

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 807 KB

english, 1995

23

Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3- d ]pyrimidines as Antifolates

Gangjee, Aleem, Zeng, Yibin, Talreja, Tina, McGuire, John J., Kisliuk, Roy L., Queener, Sherry F.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 265 KB

english, 2007

24

Synthesis of Classical and a Nonclassical 2-Amino-4-oxo-6-methyl-5-substituted Pyrrolo[2,3- d ]pyrimidine Antifolate Inhibitors of Thymidylate Synthase 1

Gangjee, Aleem, Mavandadi, Farahnaz, Kisliuk, Roy L., Queener, Sherry F.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

25

Synthesis and antifolate activity of 8,10-dideazaminopterin

Joseph I. Degraw, Lawrence F. Kelly, Roy L. Kisliuk, Yvette Gaumont, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1982

File:

PDF, 144 KB

1982

26

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

Gangjee, Aleem, Yu, Jianming, McGuire, John J., Cody, Vivian, Galitsky, Nikolai, Kisliuk, Roy L., Queener, Sherry F.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 657 KB

english, 2000

27

Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines

Gangjee, Aleem, Vidwans, Anup, Elzein, Elfatih, McGuire, John J., Queener, Sherry F., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 117 KB

english, 2001

28

Synthesis of N-[4-[1-Ethyl-2-(2,4-diaminofuro[2,3- d ]pyrimidin-5-yl)ethyl]benzoyl]- l -glutamic Acid as an Antifolate 1

Gangjee, Aleem, Zeng, Yibin, McGuire, John J., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

29

A Molecular-Scale Approach to Rare-Earth Beneficiation: Thinking Small to Avoid Large Losses

Chapleski, Robert C., Chowdhury, Azhad U., Wanhala, Anna K., Bocharova, Vera, Roy, Santanu, Keller, Philip C., Everly, Dylan, Jansone-Popova, Santa, Kisliuk, Alexander, Sacci, Robert L., Stack, Andrew

Journal:

Year:

2020

File:

PDF, 7.09 MB

2020

30

The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase

Aleem Gangjee, Mohit Kotharé, Roy L. Kisliuk

Journal:

Journal of Heterocyclic Chemistry

Year:

2000

File:

PDF, 427 KB

2000

31

Synthesis and biological activity of 5,11-methylenetetrahydro-5-deazahomofolic acid

Gangjee, Aleem, Donkor, Isaac O., Kisliuk, Roy L., Gaumont, Yvette, Thorndike, Janet

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 736 KB

english, 1991

32

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Gangjee, Aleem, Li, Wei, Yang, Jie, Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

33

Synthesis of Classical, Three-Carbon-Bridged 5-Substituted Furo[2,3- d ]pyrimidine and 6-Substituted Pyrrolo[2,3- d ]pyrimidine Analogues as Antifolates 1

Gangjee, Aleem, Zeng, Yibin, McGuire, John J., Mehraein, Farideh, Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 148 KB

english, 2004

34

Antimicrobial activity of 8-deazafolic acid

DeGraw, Joseph I., Kisliuk, Roy L., Gaumont, Yvette, Baugh, Charles M.

Journal:

Journal of Medicinal Chemistry

Year:

1974

Language:

english

File:

PDF, 275 KB

english, 1974

35

Synthesis and antifolate activity of 10-deazaminopterin

DeGraw, Joseph I., Kisliuk, Roy L., Gaumont, Yvette, Baugh, Charles M., Nair, M. G.

Journal:

Journal of Medicinal Chemistry

Year:

1974

Language:

english

File:

PDF, 273 KB

english, 1974

36

Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines

Gangjee, Aleem, Devraj, Rajesh, McGuire, John J., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.10 MB

english, 1995

37

Folate analogs altered in the C9-N10 bridge region: 11-thiohomofolic acid

Nair, M. G., Chen, Shiang-Yuan, Kisliuk, Roy L., Gaumont, Y., Strumpf, D.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 870 KB

english, 1979

38

The Phospholipases. Handbook of Lipid Research, Vol. 5by Moseley Waite

Review by: Roy L. Kisliuk

Journal:

American Scientist

Year:

1989

Language:

english

File:

PDF, 331 KB

english, 1989

39

Encyclopedia of Life Sciences || Folates

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

40

Folate analogs. 22. Synthesis and biological evaluation of two analogs of dihydrofolic acid possessing a 7,8-dihydro-8-oxapterin ring system

Nair, M. G., Salter, Otha C., Kisliuk, Roy L., Gaumont, Y.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 811 KB

english, 1983

41

THE STIMULATION OF SERINE BIOSYNTHESIS IN PIGEON LIVER EXTRACTS BY TETRAHYDROFOLIC ACID 1

Kisliuk, Roy L., Sakami, Warwick

Journal:

Journal of the American Chemical Society

Year:

1954

Language:

english

File:

PDF, 283 KB

english, 1954

42

Design, Synthesis, and Biological Activities of Classical N -{4-[2-(2-Amino-4-ethylpyrrolo[2,3- d ]pyrimidin-5-yl)ethyl]benzoyl}- l -glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents 1

Gangjee, Aleem, Yu, Jianming, Kisliuk, Roy L., Haile, William H., Sobrero, Giulia, McGuire, John J.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

43

Studies on the toxicity of amethopterin and tetrahydroamethopterin in chicks

Roy L. Kisliuk, M.R. Spivey Fox

Journal:

Archives of Biochemistry and Biophysics

Year:

1961

Language:

english

File:

PDF, 271 KB

english, 1961

44

6-Substituted 2,4-Diamino-5-methylpyrido[2,3-d]pyrimidines as Inhibitors of Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents

Gangjee, Aleem, Vasudevan, Anil, Queener, Sherry F., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.09 MB

english, 1995

45

Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase

Aleem Gangjee, Anil Vasudevant, Roy L. Kisliuk

Journal:

Journal of Heterocyclic Chemistry

Year:

1997

File:

PDF, 662 KB

1997

46

2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3- d ]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases

Gangjee, Aleem, Vasudevan, Anil, Queener, Sherry F., Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

1996

File:

PDF, 8 KB

1996

47

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5- b ]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Ihnat, Michael, Shenoy, Satyendra, Kisliuk, Roy L.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.06 MB

english, 2010

48

Tetrahydrohomofolate, a Specific Inhibitor of Thymidylate Synthetase

Goodman, Leon., Kisliuk, Roy L., Pastore, Edward J., Plante, Laurence T., Al-Nahas, Aly., Morningstar, John F., Kwok, Gregory., Wilson, Leslie., Donovan, Elaine F., Ratzan, Judith.

Journal:

Journal of the American Chemical Society

Year:

1964

Language:

english

File:

PDF, 283 KB

english, 1964

49

Classical and Nonclassical Furo[2,3-d]pyrimidines as Novel Antifolates: Synthesis and Biological Activities

Gangjee, Aleem, Devraj, Rajesh, McGuire, John J., Kisliuk, Roy L., Queener, Sherry F., Barrows, Louis R.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

50

Folate analogs. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-.gamma.-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF)

Nair, M. G., Nanavati, Nitin T., Nair, Indira G., Kisliuk, Roy L., Gaumont, Y., Hsiao, M. C., Kalman, Thomas I.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1010 KB

english, 1986

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